|
KMID : 1030220200210030105
|
|
Journal of Korean Diabetes
2020 Volume.21 No. 3 p.105 ~ p.115
|
|
|
The Effect of Long-Term Sodium-Glucose Cotransporter 2 Inhibitor Treatment on Renal Function in Patients with Type 2 Diabetes
|
|
Baek Jong-Ha
Oh Tae-Jung
Moon Ju-Young
Kim Tae-Hee
Ko Seung-Hyun
Moon Min-Kyong
Kim Hyun-Jung
Lee Dong-Won
Hur Kyu-Yeon
|
|
|
Abstract
|
|
|
Chronic kidney disease commonly develops in patients with type 2 diabetes mellitus (T2DM) and is the most common cause of end-stage renal disease and related cardiovascular complications. Meanwhile, despite the current standard of care that includes optimized glucose control and the use of single-agent blockade of the renin-angiotensin-aldosterone system (RAAS), patients with T2DM remain at increased risk for premature death and complications due to cardiorenal causes. Recent studies using sodiumglucose cotransporter 2 (SGLT2) inhibitors have shown not only glucose lowering effects, but also a reduction in blood pressure, weight loss, and lower cardiovascular risk. Regarding renal outcomes, the
use of SGLT2 inhibitors slows the progression of kidney disease compared to placebo when added to standard care. However, concern has been raised that currently available SGLT2 inhibitors in Korea may also be associated with improved renal outcomes during long-term treatment. As a result, we aimed to evaluate the effect of long-term SGLT2 inhibitor treatment on renal function in patients with T2DM using meta-analysis.
|
|
|
KEYWORD
|
|
|
Chronic kidney disease, Diabetes mellitus, type 2, Meta-analysis, Sodium-glucose cotransporter 2 inhibitor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|